Critical care medicine
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Critical care medicine · Jan 1999
Randomized Controlled Trial Clinical TrialFlumazenil in drug overdose: randomized, placebo-controlled study to assess cost effectiveness.
To investigate cost effectiveness of administration of flumazenil to patients presenting with suspected acute drug overdose. ⋯ Use of flumazenil in intentional drug overdose of unknown etiology is not cost effective.
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Critical care medicine · Jan 1999
Prognostic value of blood lactate, base deficit, and oxygen-derived variables in an LD50 model of penetrating trauma.
To determine whether blood lactate, base deficit, or oxygen-derived hemodynamic variables correlate with morbidity and mortality rates in a clinically-relevant LD50 model of penetrating trauma. ⋯ Arterial lactate is a stronger index of blood loss after penetrating trauma than base deficit or oxygen-derived hemodynamic variables. The reliability of arterial lactate depends on several factors, such as the time after injury, the proportion of survivors and nonsurvivors in the study population, and on factors other than tissue hypoxia.
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Critical care medicine · Jan 1999
Positive end-expiratory pressure redistributes perfusion to dependent lung regions in supine but not in prone lambs.
To examine the influence of positive end-expiratory pressure (PEEP) and posture on the distribution of pulmonary blood flow. ⋯ PEEP redistributes pulmonary perfusion to dependent lung regions in supine, but not in prone, anesthetized and mechanically-ventilated sheep.
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To record the number of children with withdrawal symptoms after the administration of sedatives for mechanical ventilation, and to discuss the possible connection with the administration of midazolam. ⋯ Signs and symptoms of a withdrawal reaction were observed in several children. The occurrence of withdrawal was statistically related to high doses of midazolam, but it was not possible to determine the influence of morphine. If large doses of midazolam and opioids have been administered, there may be justification for reducing the dose gradually instead of abruptly, or using longer-acting benzodiazepines or opioids on discontinuation of sedation.