Critical care medicine
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Critical care medicine · Oct 1993
Comparative StudyPredictability of creatinine clearance estimates in critically ill patients.
a) To evaluate the predictive ability of different creatinine clearance methods as compared with the criterion standard, inulin clearance; and b) to determine which of the predictive methods yields the most accurate estimation of creatinine clearance. ⋯ The utilization of the Cockcroft-Gault equation as used clinically (the lower of ideal or total body weight and the higher of actual serum creatinine or corrected serum creatinine concentration to 1 mg/dL [85 mumol/L]) results in more accurate predictions of glomerular filtration rate in the medical, critically ill patient than urine creatinine clearance measures. If creatinine clearance measures are used, the 30-min collection provided results not different from those results obtained with 24-hr urinary collections.
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To review the role of tumor necrosis factor (TNF) in the pathogenesis of the septic shock syndrome. ⋯ TNF plays a major role in the pathogenesis of the septic shock syndrome. TNF exerts a range of beneficial and injurious effects that may ultimately lead to organ dysfunction and death. The burst of TNF release after endotoxemia promotes the progression of the shock syndrome even in the absence of further TNF release. New therapies targeted to the attenuation of TNF may hold promise for the management of patients with septic shock syndrome.
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Critical care medicine · Oct 1993
Comparative StudyAccuracy of a new bedside method for estimation of circulating blood volume.
To evaluate the accuracy of a modification of the carbon monoxide method of estimating the circulating blood volume. ⋯ Determination of circulating blood volume can be performed with sufficient accuracy using an amount of carbon monoxide that gives rise to an unharmful increase in the carboxyhemoglobin concentration.