Critical care medicine
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Critical care medicine · Jul 1993
Intratracheal perfluorocarbon administration combined with mechanical ventilation in experimental respiratory distress syndrome: dose-dependent improvement of gas exchange.
To test the efficacy of intratracheal instillation of a perfluorocarbon, combined with conventional mechanical ventilation, as well as to establish the dose response of this application on pulmonary parameters in adult animals with acute respiratory failure. ⋯ The remarkable improvements in pulmonary parameters suggest that this type of ventilatory support offers an effective and simple method of perfluorocarbon application in acute respiratory failure.
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Critical care medicine · Jul 1993
Editorial CommentPerfluorocarbon liquids and respiratory support.
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Critical care medicine · Jun 1993
Randomized Controlled Trial Clinical TrialA randomized, controlled trial of aminophylline in ventilatory weaning of premature infants.
To determine whether maximal inspiratory force predicts successful neonatal extubation, and whether aminophylline affects maximal inspiratory force or the success rate of extubation. ⋯ Aminophylline is an effective prophylaxis for postextubation apnea in the preterm infant but does not affect maximal inspiratory force or increase the success rate of extubation in this patient population.
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Critical care medicine · Jun 1993
Effects of accidental trauma on cytokine and endotoxin production.
To determine the effects of accidental injury of varying severity on interleukin (IL)-1 alpha, IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha), and endotoxin release. ⋯ These results demonstrate that severe injury produces rapid, large increases in circulating concentrations of IL-6 and IL-8 that may contribute to the frequent development of the adult respiratory distress syndrome and multiple organ system failure in this clinical setting.
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Critical care medicine · Jun 1993
Weight changes in critically ill patients evaluated by fluid balances and impedance measurements.
To study simple, rapid, and predictive methods to determine body weight changes in critically ill patients. ⋯ Calculated fluid balances are not predictive for actual weight changes in critically ill patients. Absolute weight measurements are indispensable. Changes in resistance correlated with weight changes in individual patients if weight changes were > 3 kg.