Critical care medicine
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Critical care medicine · Feb 1991
Prolonged hemorrhagic shock does not impair regeneration of plasma coagulant masses in the rabbit.
Twelve adult male albino rabbits were assigned alternately to normotensive and hypotensive groups to assess the effect of hypovolemic shock on spontaneous correction of dilutional coagulopathy. All animals underwent dilutional exchange transfusion with 200 mL of rabbit RBCs and 5% human albumin. Half the animals were then acutely hemorrhaged and subsequent aliquots of blood removed as needed to maintain the mean arterial pressure at 40 mm Hg. ⋯ Dilutional coagulopathy corrects spontaneously within hours. Normovolemic shock prolongs dilutional coagulopathy not by impairment of factor regeneration but because of further (internal) dilution due to plasma expansion. Rapid correction of dilutional coagulopathy is likely to necessitate cryoprecipitate administration.
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Critical care medicine · Feb 1991
Editorial CommentAre we ready to regionalize pediatric intensive care?
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Critical care medicine · Jan 1991
Randomized Controlled Trial Comparative Study Clinical TrialRinger's lactate with or without 3% dextran-60 as volume expanders during abdominal aortic surgery.
To compare a solution of 3% dextran-60 (D60) in Ringer's lactate (RL) with RL alone as maintenance fluids for abdominal aortic surgery. ⋯ A diluted colloid solution in Ringer's lactate is of significant value in maintaining intravascular volumes and hemodynamics during and after major operative procedures.