Human psychopharmacology
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Human psychopharmacology · Jun 2008
Pregabalin in the discontinuation of long-term benzodiazepines' use.
Tolerance, dependence, and adverse effects on cognitive functions are well-known consequences of long-term use of benzodiazepines (BDZ), especially at high doses, raising thorny therapeutic problems in their discontinuation. One promising pharmacological agent in BDZ discontinuation might be the newer anti-epileptic pregabalin, already successfully tested in the treatment of anxiety disorders. ⋯ Although preliminary, our findings suggest that pregabalin may be one new promising agent in the treatment of BDZ dependence.