Human psychopharmacology
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Human psychopharmacology · Aug 2011
Randomized Controlled Trial Comparative StudyImpact of treatment approach on maternal and neonatal outcome in pregnant opioid-maintained women.
The objective of this study is to compare maternal and neonatal outcome of opioid-dependent women maintained on buprenorphine or methadone throughout pregnancy in a randomized double-blind double-dummy clinical trial (CT) with a comparison group undergoing a structured standard protocol (SP) at the Medical University of Vienna, Austria. ⋯ Comparably favorable outcome for mothers and infants and efficacy and safety of opioid medications were shown in both treatment approaches. Neonatal care could benefit from transferring successful CT procedures into clinical practice.