Epilepsy research
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Photosensitivity can be used as a model in short-term studies for assessing the efficacy of new antiepileptic drugs in man. As a quantitative measure of photosensitivity, the photosensitivity range is employed. This is the range between the highest and the lowest flash rate producing a photoparoxysmal response (generalized paroxysmal activity on the EEG). ⋯ This effect was attributable to loreclezole as no acute interactions with valproic acid could be demonstrated. The rapid onset of activity indicates that loreclezole readily passes the blood-brain barrier. The doses applied were very well tolerated.