Epilepsy research
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Review
Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25 years of research.
Over 90 investigations have been conducted over the past 25 years to determine what effect AEDs have on cognition. No satisfactory answer to this problem can be given, however, chiefly because there is a paucity of studies that pass fairly basic standards of methodology, design and analysis that apply to the evaluation of any clinical research. This severely limits the precision of statements regarding cognitive AED effects. ⋯ The choice of a study design based on a large treatment effect size may not always be appropriate, though. Of course, one could argue that it is only large effects that may be of practical or clinical significance anyways [30] and that effects of lesser magnitude are of no consequence. However, there are many examples where even a small benefit of one treatme