The Journal of arthroplasty
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Randomized Controlled Trial Clinical Trial
Transcutaneous electrical nerve stimulation for postoperative pain relief after total knee arthroplasty.
Transcutaneous electrical nerve stimulation (TENS) has been used to treat chronic pain syndromes and has been reported to be of some utility in the treatment of postsurgical pain. A randomized, blinded, placebo-controlled trial was designed to evaluate the utility of TENS after total knee arthroplasty. ⋯ There was no significant reduction in the requirement for patient-controlled analgesia with or without TENS. We conclude that there is no utility for TENS in the postoperative management of pain after knee arthroplasty.
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Clinical Trial
Celecoxib versus indomethacin in the prevention of heterotopic ossification after total hip arthroplasty.
A cyclo-oxygenase (COX)-1 and COX-2 inhibitor (indomethacin) and a selective COX-2 inhibitor (celecoxib) were compared in the prevention of heterotopic ossification after total hip arthroplasty. In 250 patients receiving indomethacin and in 150 patients receiving celecoxib for 20 days after surgery, an overall incidence of heterotopic ossification of 17.5% and 14.3% was seen, respectively (difference not statistically significant: P > .05). ⋯ Twenty-one patients in the indomethacin group (8.4%) and 3 patients in the celecoxib group (2.0%) required treatment discontinuation, because of side effects (P < .05). Celecoxib, a selective COX-2 inhibitor, shows the same efficacy as indomethacin in the prevention of heterotopic ossification after hip prosthesis with significantly fewer side effects.