Journal of Korean medical science
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J. Korean Med. Sci. · Mar 2023
Tiotropium Bromide Improves Neutrophilic Asthma by Recovering Histone Deacetylase 2 Activity.
The value of tiotropium bromide (TIO) in neutrophilic asthma was meaningful in previous study. We hypothesized that TIO's mechanism of action is associated with histone deacetylase 2 (HDAC2) activity, which is key for controlling the transcription of inflammatory cytokines and usually downregulated in neutrophilic asthma. ⋯ These results support the hypothesis that TIO modulates inflammation by recovering HDAC2 activity from the acetylcholine-stimulated inflammation cascade in neutrophilic asthma. The detailed inflammation cascade of recovering HDAC2 activity by TIO might be associated with PLCγ-1-IP3-IP3R mediated intracellular calcium ion pathway.
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J. Korean Med. Sci. · Mar 2023
ReviewThe Cultural Context of Plagiarism and Research Misconduct in the Asian Region.
Plagiarism is one of the most frequent forms of research misconduct in South and East Asian countries. This narrative review examines the factors contributing to research misconduct, emphasizing plagiarism, particularly in South, East and Southeast Asian countries. We conducted a PubMed and Scopus search using the terms plagiarism, Asia, South Asia, East Asia, Southeast Asia, research misconduct and retractions in January of 2022. ⋯ Researchers lack training in scientific writing, and substantial gaps exist in understanding various forms of plagiarism, which heavily contribute to the problem. There is an urgent need to foster high research ethics standards and adhere to journal policies. Providing appropriate training in scientific writing among researchers may help improve the knowledge of different types of plagiarism and promote the use of antiplagiarism software, leading to a substantial reduction in the problem.
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J. Korean Med. Sci. · Mar 2023
Multicenter StudyNon-Arteritic Ischemic Optic Neuropathy Following COVID-19 Vaccination in Korea: A Case Series.
To report the clinical manifestations of non-arteritic anterior ischemic optic neuropathy (NAION) cases after coronavirus disease 2019 (COVID-19) vaccination in Korea. ⋯ Only 64% of patients with NAION after COVID-19 vaccination have known vascular and ocular risk factors relevant to ischemic optic neuropathy. This suggests that COVID-19 vaccination may increase the risk of NAION. However, overall clinical features and visual outcomes of the NAION patients after COVID-19 vaccination were similar to those of typical NAION.
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J. Korean Med. Sci. · Mar 2023
Weight Gain, Comorbidities, and Its Associated Factors Among Korean Adults.
Weight gain in adults is associated with an increased risk of obesity-related diseases and high healthcare costs. However, there have been limited studies on weight gain in Asians. This study investigated the prevalence, comorbidities, and associated factors of weight gain in the Korean population. ⋯ Weight gain was much more pronounced in younger adults and at a higher baseline BMI in both sexes. Public education and health policies to prevent unnecessary weight gain should be strengthened by considering the associated harmful factors in Korean adults.