Annals of vascular surgery
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Randomized Controlled Trial Multicenter Study Comparative Study
Use of fibrin sealant as a hemostatic agent in expanded polytetrafluoroethylene graft placement surgery.
The low thrombogenicity, porosity, and limited elasticity of expanded polytetrafluoroethylene (ePTFE) vascular grafts, although beneficial, may exacerbate the problem of suture-line bleeding at vascular anastomoses and consequently lead to increased operating times. The overall objective of this prospective, randomized, controlled, subject-blinded, multicenter phase 2 study was to evaluate the efficacy and safety of a fibrin sealant containing 500 IU/mL thrombin and synthetic aprotinin (FS; marketed in the United States under the name TISSEEL) for hemostasis in subjects undergoing vascular surgery and receiving prosthetic ePTFE vascular grafts. ⋯ The findings from this phase 2 study support the strong safety profile of FS and suggest that it is an efficacious hemostatic agent in ePTFE graft placement surgery, as well as a useful tool in peripheral vascular surgery applications.
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Randomized Controlled Trial
Correlation of intraoperative collateral perfusion pressure during carotid endarterectomy and status of the contralateral carotid artery and collateral cerebral blood flow.
The optimal method for predicting when carotid shunting is not necessary during carotid endarterectomy (CEA) is controversial. This study will analyze the correlation of collateral perfusion pressure and the status of contralateral carotid/cerebral collaterals and determine whether preoperative duplex ultrasound/cerebral angiography can predict when CEA can be done without shunting. ⋯ There was an inverse correlation between collateral perfusion pressure and severity of contralateral carotid stenosis, and patients with severe contralateral carotid stenosis/occlusion were more likely to be shunted. The presence of cross-filling with normal to <70% contralateral carotid stenosis was associated with a collateral perfusion stump pressure of ≥40 mm Hg in 100% of patients for whom shunting was not carried out in our series.