Journal of clinical pharmacy and therapeutics
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Atracurium besylate (AB) is supplied as a sterile, non-pyrogenic aqueous solution for intravenous use. Hospitals pre-fill disposable plastic syringes with these solutions so that they are ready for immediate use when required. Drug loss due to potential adsorption on to the plastic material of the syringes has not been studied. ⋯ Refrigeration was observed to improve drug stability. The manufacturer's recommended expiry period was too conservative. Storage at room temperature for up to 6 weeks can be safely recommended, without significant loss of chemical stability.
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Over the last 5-10 years, there has been significant growth in the knowledge and strategies of pain management in children. Investigations are required to discern whether concomitant improvements in clinical practice have occurred. The purpose of this study was to identify the nurses' administration of a traditional analgesic (acetaminophen) with regard to appropriate doses and time intervals. ⋯ The prevalence of pain amongst the children was high both before and after analgesics, indicating that acetaminophen in the doses used did not provide any significant measure of pain relief. Current practice is still not optimal. Educating nurses on the effective use of traditional pain therapies may improve paediatric pain management.