Journal of clinical pharmacy and therapeutics
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Review Comparative Study
Do codeine and caffeine enhance the analgesic effect of aspirin?--A systematic overview.
To assess whether codeine and caffeine enhance the analgesic effect of aspirin in post-operative pain. ⋯ Codeine 60 mg may produce a small increase in the analgesic effect of aspirin 650 mg. However, this effect is not clinically meaningful. Caffeine has no adjuvant analgesic effect. At over-the-counter (OTC) doses, caffeine and codeine are not useful in aspirin formulations.