Journal of clinical pharmacy and therapeutics
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Clinical Trial Controlled Clinical Trial
Appropriateness of a 4 mg/kg gentamicin or tobramycin loading dose in post-operative septic shock patients.
To determine the frequency with which early adequate peak serum concentrations (6-12 mg/ litre) can be achieved following a 4 mg/kg loading dose of gentamicin or tobramycin in post-operative septic shock patients. ⋯ One hundred per cent of the post-operative septic shock patients achieved target peak serum concentrations (mean 8.9+/-2.2 mg/litre) following a 4 mg/kg tobramycin or gentamicin loading dose. An expanded Vd (0.46+/-0.13 litres/kg) was also observed.
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Comparative Study Clinical Trial
Aminoglycoside pharmacokinetics in African-Americans with normal renal function.
To compare aminoglycoside pharmacokinetics in African-Americans with normal renal function with published adult population values. ⋯ We conclude that aminoglycoside pharmacokinetics in African-Americans seem to be consistent with the published general population values. Thus, initiating aminoglycoside regimens using population dosing guidelines appears to be appropriate. However, due to the observed wide interpatient pharmacokinetic variability, individualized dosing is required with very close monitoring, to avoid or minimize toxicity.