Journal of clinical pharmacy and therapeutics
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Case Reports
Prevention of post-operative hyperalgesia in a heroin-addicted patient on methadone maintenance.
The exponential increase in chronic opioid consumers resulted in more challenges regarding post-operative pain management. Considering the usual hyperalgesic response to pain and the increased opioid-tolerance, a multidrug approach should be desirable. ⋯ Ketamine can effectively reduce opioid requirements in chronic opioid users on methadone maintenance therapy and should therefore be considered promptly as part of a multimodal perioperative analgesia management in this category of patients.