Journal of the American Academy of Child and Adolescent Psychiatry
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J Am Acad Child Adolesc Psychiatry · Feb 2009
Randomized Controlled Trial Multicenter StudyGuanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder: a placebo-controlled trial.
This study compared the efficacy of guanfacine extended release (GXR), a selective alpha(2A)-adrenoceptor agonist, with placebo in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). ⋯ : Guanfacine extended-release was effective in reducing symptoms of ADHD. Adverse events were mild to moderate, did not interfere with improvements in attention, and rarely led to discontinuation.