Palliative medicine
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Palliative medicine · Dec 2021
Randomized Controlled TrialVirtual reality for pain management in advanced heart failure: A randomized controlled study.
Hospitalized patients with advanced heart failure often experience acute and/or chronic pain. While virtual reality has been extensively studied across a wide range of clinical settings, no studies have yet evaluated potential impact on pain management on this patient population. ⋯ Virtual reality may be an effective nonpharmacologic adjuvant pain management intervention in hospitalized patients with heart failure.
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Palliative medicine · Dec 2021
Performance status and trial site-level factors are associated with missing data in palliative care trials: An individual participant-level data analysis of 10 phase 3 trials.
Missing data compromise the internal and external validity of trial findings, however there is limited evidence on how best to reduce missing data in palliative care trials. ⋯ Participants with a poorer performance status are at higher risk of missing data in palliative care trials and require additional support to provide complete data. Performance status is a potential auxiliary variable for missing data imputation models. Reducing trial variability should be prioritised and further factors need to be identified and explored to explain the residual variance.
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Palliative medicine · Dec 2021
Outcomes and measures of delirium interventional studies in palliative care to inform a core outcome set: A systematic review.
Trials of interventions for delirium in various patient populations report disparate outcomes and measures but little is known about those used in palliative care trials. A core outcome set promotes consistency of outcome selection and measurement. ⋯ The review identified few delirium interventions with heterogeneity in outcomes, their definition and measurement, highlighting the need for a uniform approach. Findings will inform the next stage to develop consensus for a core outcome set to inform delirium interventional palliative care research.