Acta radiologica
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Changes in T2 relaxation time (T2-TR) and apparent diffusion coefficients (ADC) have been suggested to appear in the intervertebral disc before morphological changes. Such sensitive imaging methods could be beneficial in the targeting and follow-up of intradiscal gene therapy. ⋯ Early traumatic or degenerative changes are detectable with both T2-TR and ADC. The ADC in the early phase after experimental trauma seems to initially increase before decreasing.