Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
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Nephrol. Dial. Transplant. · Nov 2005
Comparative StudyLong-term results in renal transplant patients with allograft dysfunction after switching from calcineurin inhibitors to sirolimus.
Switching from calcineurin inhibitors (CNIs) to sirolimus might improve renal function in chronic renal transplant patients. ⋯ Conversion from CNIs to sirolimus in renal transplant patients with chronic allograft nephropathy was associated with improved renal function; however, 33% of the patients developed overt proteinuria.
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Nephrol. Dial. Transplant. · Nov 2005
Comparative StudyLong-term effects of cyclosporine in children with idiopathic nephrotic syndrome: a single-centre experience.
Because of its potential nephrotoxicity, the long-term use of cyclosporine (CsA) as treatment for nephrotic syndrome (NS) is controversial. The clinical outcome of the patients with NS treated with CsA is unclear. ⋯ Long-term CsA therapy in low doses is effective in the treatment of children with idiopathic NS, but the rate of relapse is high after drug withdrawal. Hypertension developed in 10% of patients and renal insufficiency in 6% (most patients with FSGS).
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Nephrol. Dial. Transplant. · Nov 2005
Comparative StudyEvaluation of tests for microalbuminuria screening in patients with diabetes.
The first step in the diagnosis of diabetic nephropathy is to measure albumin in a spot urine sample. The aim of this study was to assess the accuracy of urinary albumin concentration (UAC), urinary albumin-to-creatinine ratio (UACR), and the Micral-Test II in a random urine specimen (RUS) for microalbuminuria screening in diabetes mellitus. ⋯ Measurement of UAC in a RUS was the best choice for the diagnosis screening of microalbuminuria in diabetic patients, considering cost and accuracy.
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Nephrol. Dial. Transplant. · Nov 2005
Comparative StudyGFR prediction using the MDRD and Cockcroft and Gault equations in patients with end-stage renal disease.
Although prediction equations are recommended to determine GFR and creatinine clearance (CrCl), neither the MDRD equations nor the Cockcroft and Gault formula have been validated for the low levels of GFR present in end-stage renal disease (ESRD). The accuracy of the MDRD equations and the Cockcroft and Gault formula in predicting GFR and CrCl, respectively, was examined in patients with ESRD and its relationship to the basal GFR and two markers of malnutrition, urinary creatinine and body fat determined. ⋯ The MDRD equations were more accurate in predicting the group mean GFR in patients with ESRD than the Cockcroft and Gault formula. However, the predicted GFR using either formula was related to the basal GFR and percentage body fat.