Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Dec 1999
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialComparison of racecadotril and loperamide in children with acute diarrhoea.
A multicentre, parallel-group, double-blind, double-placebo study was carried out to compare the efficacy, tolerability, and safety of racecadotril and loperamide in children aged 2 to 10 years who were suffering from acute diarrhoea. Patients received racecadotril (1.5 mg/kg) or loperamide (0.03 mg/kg) three times daily plus matching placebo until recovery. Fifty-two children received racecadotril and 50 loperamide. ⋯ Racecadotril and loperamide were equally effective in treating acute diarrhoea in these children, and racecadotril had a superior tolerability and safety profile.