Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Apr 1999
Randomized Controlled Trial Clinical TrialTreatment options for Helicobacter pylori infection when proton pump inhibitor-based triple therapy fails in clinical practice.
The effectiveness of Helicobacter pylori eradication regimens has not been extensively investigated in the clinical practice setting. The optimal treatment choice after an initial failed eradication attempt has not been determined. ⋯ The eradication rates achieved in this 'in practice' study with recommended first-line 1-week proton pump inhibitor-based triple therapy regimens were lower than the rates achieved with similar regimens in the clinical trial setting. A repeat 1-week proton pump inhibitor-based triple therapy regimen was not successful as a salvage therapy. Both the 2-week proton pump inhibitor-based triple therapy regimen and the 1-week quadruple therapy regimen were successful second-line treatments in >/=75% of patients.