Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Sep 2000
Randomized Controlled Trial Clinical TrialSedation with propofol plus midazolam versus propofol alone for interventional endoscopic procedures: a prospective, randomized study.
Adequate patient sedation is mandatory for most interventional endoscopic procedures. Recent anaesthesiologic studies indicates that propofol and midazolam act synergistically in combination and therefore may be superior to sedation with propofol alone in terms of sedation efficacy, recovery and costs (due to a presumed lower total dose of propofol needed). ⋯ During therapeutic endoscopy, sedation with propofol and midazolam requires a lower total dose of propofol, but otherwise has no superior sedation efficacy and is associated with a slower post-procedure recovery than sedation with propofol alone.