Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Jun 2001
Occurrence and relapse of bleeding from duodenal ulcer: respective roles of acid secretion and Helicobacter pylori infection.
Helicobacter pylori infection, gastric acid hypersecretion and NSAID consumption may cause peptic ulcer. ⋯ In H. pylori-positive duodenal ulcer patients, the coexistence of elevated basal acid output and pentagastrin acid output leads to a sixfold increase in the risk of bleeding. After H. pylori cure, gastric acid hypersecretion is not a risk factor for bleeding. However, duodenal ulcer recurrence with bleeding may occasionally occur in patients cured of H. pylori, even if acid output is normal.
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Aliment. Pharmacol. Ther. · Jun 2001
Randomized Controlled Trial Clinical TrialPharmacodynamic effects and kinetic disposition of rabeprazole in relation to CYP2C19 genotypes.
S-mephenytoin 4'-hydroxylase (CYP2C19) catalyses the metabolism of rabeprazole to some extent. Based on the metabolic and pharmacokinetic differences among other proton pump inhibitors such as omeprazole, lansoprazole and pantoprazole, rabeprazole appears to be the least affected proton pump inhibitor by the CYP2C19-related genetic polymorphism. ⋯ The pharmacodynamic effects of rabeprazole and its pharmacokinetics depend on the CYP2C19 genotype status.