Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · May 2003
Review Comparative StudySystematic review: Antacids, H2-receptor antagonists, prokinetics, bismuth and sucralfate therapy for non-ulcer dyspepsia.
Evidence for the effectiveness of antacids, histamine-2 receptor antagonists, bismuth salts, sucralfate and prokinetic therapy in non-ulcer dyspepsia is conflicting. ⋯ The meta-analyses suggest that histamine-2 receptor antagonists and prokinetics are superior to placebo. These data are difficult to interpret, however, as funnel plot asymmetry suggests that the magnitude of the effect could be due to publication bias or other heterogeneity-related issues.
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Aliment. Pharmacol. Ther. · May 2003
Diverticular disease of the colon--on the rise: a study of hospital admissions in England between 1989/1990 and 1999/2000.
Diverticular disease emerged as a common problem in Western countries over the course of the 20th century. ⋯ Admission rates for diverticular disease increased over the study period. The proportion of patients who underwent operation increased, but in-patient and population mortality rates remained unchanged. With an ageing population, diverticular disease will become an increasingly important clinical problem in England.