Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Feb 2005
Randomized Controlled Trial Multicenter Study Clinical TrialSymptomatic efficacy of beidellitic montmorillonite in irritable bowel syndrome: a randomized, controlled trial.
Beidellitic montmorillonite is a purified clay containing a double aluminium and magnesium silicate. ⋯ Although pain or discomfort was not significantly improved in the entire IBS population treated with beidellitic montmorillonite in comparison with placebo, this study demonstrates that beidellitic montmorillonite is efficient for C-IBS patients (P < 0.016). This effect of beidellitic montmorillonite on pain cannot be explained by changes in bowel habits. The efficacy of this well-tolerated therapy warrants further confirmatory therapeutic trials in C-IBS patients.