Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Apr 2005
Randomized Controlled Trial Clinical TrialA controlled trial of ondansetron in the pruritus of cholestasis.
In patients with pruritus of cholestasis, response to conventional drug treatment may be unsatisfactory. Activation of 5-hydroxytryptamine receptors on dermal sensory nerve-endings plays a role in the perception of pruritus. The 5-hydroxytryptamine(3) receptor antagonist, ondansetron, has been used in the treatment of pruritus of cholestasis, but there are few controlled data. ⋯ Ondansetron was of no benefit in this group of pruritic patients during short-term treatment.