Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Feb 2006
Efficacy and safety of rifabutin-containing 'rescue therapy' for resistant Helicobacter pylori infection.
Current 'rescue' therapies provide inadequate Helicobacter pylori eradication rates because of antibiotic resistance. ⋯ A 12-day course of low dose of rifabutin with an increased dose of amoxicillin and pantoprazole is well-tolerated and highly effective against dual-resistant H. pylori infection after failure of triple therapy.
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Aliment. Pharmacol. Ther. · Feb 2006
Randomized Controlled TrialLansoprazole, levofloxacin and amoxicillin triple therapy vs. quadruple therapy as second-line treatment of resistant Helicobacter pylori infection.
To test the efficacy of levofloxacin-based second-line therapy for resistant Helicobacter pylori infection. ⋯ Lansoprazole, amoxicillin plus levofloxacin second-line therapy is comparable with quadruple therapy in efficacy. Subjects, especially those with dual resistance to metronidazole and clarithromycin, may consider levofloxacin-based therapy for levofloxacin-sensitive strains.