Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Sep 2006
Review Meta AnalysisMeta-analysis: terlipressin therapy for the hepatorenal syndrome.
The hepatorenal syndrome is a severe and well-known complication of end-stage liver disease, but its management is controversial. Recent reports have shown the efficacy of terlipressin therapy, a vasopressin analogue, in hepatorenal syndrome patients. ⋯ This meta-analysis shows efficacy and safety of terlipressin in the treatment of hepatorenal syndrome. However, a significant number of responder patients relapsed after terlipressin withdrawal. Further studies are in progress to address the link between terlipressin and survival in hepatorenal syndrome patients.
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Aliment. Pharmacol. Ther. · Sep 2006
Randomized Controlled TrialDouble-blind, randomized, placebo-controlled study to evaluate the effects of tegaserod on gastric motor, sensory and myoelectric function in healthy volunteers.
The effects of tegaserod on gastric accommodation and postprandial satiety remain unclear. ⋯ While tegaserod decreased proximal gastric volume change after a meal, it does not appear to have significant effects on gastric motor and sensory function in healthy individuals. Further studies are required in patients with disturbances of gastric motor and sensory function.