Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Dec 2008
ReviewReview article: pharmacological therapy for hepatocellular carcinoma with sorafenib and other oral agents.
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. Unresectable disease patients have median survival of few months. There is a substantial need for novel treatments for patients with advanced HCC. ⋯ Currently available therapies are not effective for patients with advanced HCC. Sorafenib has demonstrated for the first time to prolong survival in patients with advanced HCC, and it is the new reference standard for systemic treatment in these patients.