Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Sep 2009
Development and content validity of a gastroparesis cardinal symptom index daily diary.
The Gastroparesis Cardinal Symptom Index (GCSI) is a patient-reported outcome for gastroparesis using a two-week recall period. To minimize potential patient recall effects, a daily diary version of the GCSI (GCSI-DD) was developed. ⋯ The GCSI-DD includes symptoms relevant to patients with gastroparesis, captures daily variability of those symptoms and has psychometric properties consistent with a good patient-reported outcome endpoint for gastroparesis clinical trials.
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Aliment. Pharmacol. Ther. · Sep 2009
ReviewReview article: the current and evolving treatment of colonic diverticular disease.
Formation of colonic diverticula, via herniation of the colonic wall, is responsible for the development of diverticulosis and consequently diverticular disease. Diverticular disease can be associated with numerous debilitating abdominal and gastrointestinal symptoms (including pain, bloating, nausea, constipation and diarrhoea). ⋯ Data suggest that diverticular disease may share many of the hallmarks of other, better-characterized inflammatory bowel diseases; however, treatment options for patients with diverticular disease are scarce, revolving around antibiotic treatment and surgery. There is a need for a better understanding of the fundamental mechanisms of diverticular disease to design treatment regimens accordingly.
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Aliment. Pharmacol. Ther. · Sep 2009
Multicenter Study Comparative StudyPredictors of health-related quality of life in patients with chronic liver disease.
Patient-reported outcomes like health-related quality of life (HRQL) have become increasingly important for full assessment of patients with chronic liver diseases (CLD). ⋯ Analysis of this large CLD cohort suggests that a number of important clinicodemographic factors are associated with HRQL impairment. These findings contribute to the full understanding of the total impact of CLD on patients' health.
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Aliment. Pharmacol. Ther. · Sep 2009
ReviewSystematic review: hepatitis-associated aplastic anaemia--a syndrome associated with abnormal immunological function.
Hepatitis-associated aplastic anaemia is a syndrome in which marrow failure follows the development of hepatitis. ⋯ Hepatitis-associated bone marrow aplasia is mediated by immunological mechanisms. Treatment options include hematopoietic cell transplantation and immunosuppressive therapy.