Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Oct 2010
The effects of high-dose esomeprazole on gastric and oesophageal acid exposure and molecular markers in Barrett's oesophagus.
Acid reflux is often difficult to control medically. ⋯ High-dose esomeprazole achieved higher levels of gastric acid suppression and control of oesophageal acid reflux and symptoms, with significant decreases in inflammation and epithelial proliferation. There was no reversal of aberrant DNA methylation.
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Aliment. Pharmacol. Ther. · Oct 2010
Randomized Controlled TrialThe effects of methylnaltrexone alone and in combination with acutely administered codeine on gastrointestinal and colonic transit in health.
The short-term effects of methylnaltrexone (MNTX), a peripherally acting mu-opioid receptor antagonist, on gastrointestinal and colonic transit remain unclear. ⋯ Methylnaltrexone does not alter gastrointestinal or colonic transit and does not reverse acute codeine-associated delayed gut transit in health.