Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Aug 2014
Mortality after total colectomy in 3084 patients with inflammatory bowel disease: a population-based cohort study.
A high post-operative mortality has been reported following colectomy in patients with inflammatory bowel disease (IBD), especially in some patient groups. ⋯ The 40-day mortality following total colectomy in IBD patients in Sweden is low, except in patients ≥59 years old.
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Aliment. Pharmacol. Ther. · Aug 2014
Clinical TrialEfficacy of the neurokinin-1 receptor antagonist aprepitant in children with cyclical vomiting syndrome.
Aprepitant (Emend, Merck Sharp & Dohme Ltd, Haarlem, the Netherlands), a neurokinin-1 receptor antagonist, prevents vomiting in a range of conditions. No data are available on its use in children with cyclical vomiting syndrome (CVS). ⋯ Aprepitant appears effective for both acute and prophylactic management of paediatric cyclical vomiting syndrome refractory to conventional therapies.
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Aliment. Pharmacol. Ther. · Aug 2014
Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders.
Intestinal permeability has been studied in small groups of IBS patients with contrasting findings. ⋯ Small intestinal permeability is increased in patients with IBS-D compared to healthy controls, irrespective of confounding factors. Adjustment for confounders is necessary when studying intestinal permeability, especially in a heterogeneous disorder such as IBS.