Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Dec 2016
Observational StudyConcomitant use of direct-acting antivirals and chemotherapy in hepatitis C virus-infected patients with cancer.
Antiviral therapy improves hepatic outcomes in hepatitis C virus (HCV)-infected cancer patients. However, such patients are not treated simultaneously with antivirals and chemotherapy, owing to overlapping toxicities with previous standard of care treatment of pegylated interferon and ribavirin. ⋯ Hepatitis C virus-targeted antiviral therapy can be used concomitantly with selected anti-neoplastic agents under close monitoring for drug-drug interactions. This therapeutic intervention may prevent delay in the administration of chemotherapy in HCV-infected cancer patients.