Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Sep 2016
Multicenter StudyThe safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn's disease - a phase 1 trial with three doses.
Mesenchymal stromal cells ability to reset immune functionalities may be useful in Crohn's disease. ⋯ Single infusion of fresh autologous bone marrow mesenchymal stromal cells propagated ex vivo using human platelet lysate-supplemented media was safe and feasible at intravenous doses of up to 10 million cells/kg BW in patients with Crohn's disease.