Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Dec 2018
Systematic review with network meta-analysis: the impact of medical interventions for moderate-to-severe ulcerative colitis on health-related quality of life.
Patient-reported outcomes are important in the assessment of efficacy of intervention for ulcerative colitis (UC). ⋯ Induction treatment with infliximab, adalimumab, golimumab, vedolizumab or tofacitinib improves quality of life compared to placebo. Evidence on maintenance therapy is sparse and uncertain. Head-to-head comparisons could enhance confidence in conclusions about differences between drugs in terms of HRQL.