Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Jul 2018
Randomized Controlled Trial Multicenter StudyRandomised clinical trial: Tong-Xie-Yao-Fang granules versus placebo for patients with diarrhoea-predominant irritable bowel syndrome.
Tong-Xie-Yao-Fang (TXYF) is a Chinese herbal formula for treating chronic diarrhoea accompanied by abdominal pain. The results were inconsistent in previous trials examining its effect. ⋯ During a 4 week trial, TXFY granules were superior to placebo in controlling symptoms of IBS-D.
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Aliment. Pharmacol. Ther. · Jul 2018
Randomized Controlled Trial Multicenter StudyLong-term efficacy and safety of ustekinumab for Crohn's disease through the second year of therapy.
In Phase 3 studies of ustekinumab, a fully human monoclonal IL-12/23p40 antibody approved for moderate-to-severe Crohn's disease, patients entered a long-term extension after completing 8 weeks of induction and 44 weeks of maintenance treatment. Efficacy through 92 weeks and safety through 96 weeks of IM-UNITI maintenance are reported. ⋯ Subcutaneous ustekinumab maintained clinical response and remission through Week 92. No new safety signals were observed. ClinicalTrials.gov number NCT01369355.