Alimentary pharmacology & therapeutics
-
Aliment. Pharmacol. Ther. · Oct 2019
ReviewReview article: immune checkpoint inhibitors and the liver, from therapeutic efficacy to side effects.
Immune checkpoint inhibitors have revolutionised the oncological landscape in the last few years. Possible applications include the treatment of hepatocellular carcinoma and cholangiocarcinoma. Unfortunately, new immune-related adverse effects have been associated with the use of these agents and the liver is one of the organs most frequently involved. ⋯ Immune checkpoint inhibitors represent an exciting new class of drugs with currently limited application in malignant and non-malignant liver disease. Caution must be exercised on the emergence of potentially severe immune adverse reactions.