Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Apr 2019
Clinical TrialA prospective study of the incidence of drug-induced liver injury by the modern volatile anaesthetics sevoflurane and desflurane.
Volatile anaesthetics are known to cause drug-induced liver injury, a hepatotoxic reaction characterised by antibodies to trifluoroacetylated lipid and protein adducts and cytochrome p450 2E1. The incidence of volatile anaesthetic drug-induced liver injury from older agents has been described, but modern agents have not been prospectively studied. ⋯ Volatile anaesthetic drug-induced liver injury from modern agents seems to be as common (4.1%) as previously reported with older agents (3%), and may identify patients at risk of severe acute liver injury with subsequent re-exposure.