Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Oct 1996
Clinical Trial Controlled Clinical TrialInfluence of loperamide on lactose handling and oral-caecal transit time.
The influence of pharmacologically prolonged oral caecal transit time on lactose handling is examined in the wake of finding improved lactose handling during naturally occurring prolonged oral-caecal transit time. ⋯ Loperamide-induced graded prolongation of oral-caecal transit time is associated with significantly improved lactose handling as measured by a reduction of the area under the curve. Symptoms of lactose intolerance may also be improved with loperamide. Prolongation of oral-caecal transit time with loperamide may be useful as adjunctive or primary therapy of carbohydrate intolerance in patients with rapid transit.
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Aliment. Pharmacol. Ther. · Aug 1996
Randomized Controlled Trial Comparative Study Clinical TrialSymptomatic and endoscopic duodenal ulcer relapse rates 12 months following Helicobacter pylori eradication treatment with omeprazole and amoxycillin with or without metronidazole.
To determine the effect of Helicobacter pylori eradication with omeprazole and amoxycillin, with or without metronidazole, on the 12-month course of duodenal ulcer disease. ⋯ OAM eradicates H. pylori in significantly more patients than OA, but successful H. pylori eradication with either OAM or OA predisposes to low endoscopic and symptomatic relapse rates for duodenal ulcer patients when followed up for 12 months.
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Aliment. Pharmacol. Ther. · Feb 1996
Ropivacaine gel in active distal ulcerative colitis and proctitis -- a pharmacokinetic and exploratory clinical study.
Local anaesthetics have anti-inflammatory effects as indicated by preclinical and explorative clinical data. ⋯ Ropivacaine given rectally as a gel, 200 mg twice daily does not accumulate over a 2-week treatment period and carries a low risk for systemic adverse effects. The results suggest a therapeutic efficacy in active distal ulcerative colitis.
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Aliment. Pharmacol. Ther. · Apr 1995
Randomized Controlled Trial Clinical TrialEffect of D2-dopamine receptor antagonist levosulpiride on diabetic cholecystoparesis: a double-blind crossover study.
Abnormal gall-bladder motility has been reported in diabetics. The objective was to evaluate the effect of chronic D2-dopamine receptor inhibition on gall-bladder emptying in diabetic patients. ⋯ These results show that chronic oral administration of the D2-dopamine antagonist levosulpiride has a significant effect on gall-bladder motility in diabetic patients.
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Aliment. Pharmacol. Ther. · Oct 1994
Randomized Controlled Trial Comparative Study Clinical TrialLow dose aspirin: selective inhibition of rectal dialysis thromboxane B2 in healthy volunteers.
To investigate the degree and selectivity of rectal thromboxane inhibition by low dose aspirin and there by investigate the contribution of platelet thromboxane to rectal thromboxane. ⋯ Low dose aspirin will selectively inhibit a proportion of rectal thromboxane and may have prophylactic therapeutic potential in inflammatory bowel disease.