Alimentary pharmacology & therapeutics
-
Aliment. Pharmacol. Ther. · Jul 2018
Randomized Controlled Trial Multicenter StudyRandomised clinical trial: Tong-Xie-Yao-Fang granules versus placebo for patients with diarrhoea-predominant irritable bowel syndrome.
Tong-Xie-Yao-Fang (TXYF) is a Chinese herbal formula for treating chronic diarrhoea accompanied by abdominal pain. The results were inconsistent in previous trials examining its effect. ⋯ During a 4 week trial, TXFY granules were superior to placebo in controlling symptoms of IBS-D.
-
Aliment. Pharmacol. Ther. · Jul 2018
Randomized Controlled Trial Multicenter StudyLong-term efficacy and safety of ustekinumab for Crohn's disease through the second year of therapy.
In Phase 3 studies of ustekinumab, a fully human monoclonal IL-12/23p40 antibody approved for moderate-to-severe Crohn's disease, patients entered a long-term extension after completing 8 weeks of induction and 44 weeks of maintenance treatment. Efficacy through 92 weeks and safety through 96 weeks of IM-UNITI maintenance are reported. ⋯ Subcutaneous ustekinumab maintained clinical response and remission through Week 92. No new safety signals were observed. ClinicalTrials.gov number NCT01369355.
-
Aliment. Pharmacol. Ther. · Jun 2018
Stabilisation of acute-on-chronic liver failure patients before liver transplantation predicts post-transplant survival.
Acute-on-chronic liver failure (ACLF) is a severe complication of liver cirrhosis associated with excess short-term mortality rates. Orthotopic liver transplantation (OLT) is a potentially life-saving therapeutic modality for acute-on-chronic liver failure patients, but selection of transplant candidates with an acceptable post-transplant outcome is difficult. ⋯ Acute-on-chronic liver failure predicts adverse outcome after orthotopic liver transplantation. Given the dismal prognosis without transplantation, however, our results indicate that ACLF patients can be transplanted with comparably good outcomes, in particular patients who improve under conservative therapeutic measures.