Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Sep 2009
ReviewSystematic review: hepatitis-associated aplastic anaemia--a syndrome associated with abnormal immunological function.
Hepatitis-associated aplastic anaemia is a syndrome in which marrow failure follows the development of hepatitis. ⋯ Hepatitis-associated bone marrow aplasia is mediated by immunological mechanisms. Treatment options include hematopoietic cell transplantation and immunosuppressive therapy.
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Aliment. Pharmacol. Ther. · Aug 2009
Randomized Controlled TrialEffect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof-of-concept study.
Intestinal immune infiltration contributes to symptoms in patients with irritable bowel syndrome (IBS). ⋯ Mesalazine is an effective and safe approach to reduce mast cell infiltration and may improve general well-being in patients with IBS. These results support the hypothesis that immune mechanisms represent potential therapeutic targets in IBS.
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Aliment. Pharmacol. Ther. · Aug 2009
Comment Letter Comparative StudyFentanyl vs. pethidine as sedation for gastrointestinal endoscopy.
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Aliment. Pharmacol. Ther. · Jul 2009
Randomized Controlled Trial Multicenter Study Comparative StudyClinical trial: intragastric acid control in patients who have Barrett's oesophagus--comparison of once- and twice-daily regimens of esomeprazole and lansoprazole.
Gastric acid control is important for treatment of gastro-oesophageal reflux disease associated with Barrett's oesophagus. Substantial indirect evidence suggests that gastric acid control may have a chemopreventive role in Barrett's oesophagus. ⋯ Esomeprazole 40 mg is significantly more effective than lansoprazole 30 mg in controlling intragastric pH with Barrett's oesophagus.
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Aliment. Pharmacol. Ther. · Jul 2009
ReviewReview article: the diagnosis and management of alcoholic hepatitis.
Alcoholic hepatitis is a severe, cholestatic liver disease occurring in patients with alcohol abuse. Mortality is substantial; however, therapies may improve clinical outcomes. ⋯ Severe alcoholic hepatitis is a clinically-diagnosed condition associated with significant mortality. Alcohol abstinence and nutritional therapy have been associated with improved clinical parameters and should be considered in all patients. Corticosteroid therapy and pentoxifylline therapy appear to show moderate survival benefit and should be considered as first-line therapeutic agents.