Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Jan 2009
Randomized Controlled TrialOn-demand requirements of patients with endoscopy-negative gastro-oesophageal reflux disease: H2-blocker vs. proton pump inhibitor.
It is questionable whether a symptomatic condition with few serious medical consequences requires proton pump inhibitor (PPI) treatment. If effective, a less-potent treatment may be preferable. ⋯ On-demand treatment in patients with endoscopy-negative GERD gives a high success rate with a fairly low dose of PPI. The H2-blocker had significantly less success; nevertheless, almost half were satisfied with the treatment.
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Aliment. Pharmacol. Ther. · Jan 2009
The prevalence, clinical features and association of HLA-B27 in sacroiliitis associated with established Crohn's disease.
Sacroiliitis is a recognized complication of Crohn's disease and may occur distinct from progressive ankylosing spondylitis (AS). ⋯ Sacroiliitis is common in patients with established Crohn's disease and in the majority of cases, patients have symptoms of inflammatory low back pain if questioned carefully. HLA-B27 is not associated with isolated sacroiliitis, but is associated with AS. However, possession of HLA-B27 appears to convey a very high risk of developing axial inflammation in Crohn's disease.
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Aliment. Pharmacol. Ther. · Dec 2008
ReviewReview article: pharmacological therapy for hepatocellular carcinoma with sorafenib and other oral agents.
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. Unresectable disease patients have median survival of few months. There is a substantial need for novel treatments for patients with advanced HCC. ⋯ Currently available therapies are not effective for patients with advanced HCC. Sorafenib has demonstrated for the first time to prolong survival in patients with advanced HCC, and it is the new reference standard for systemic treatment in these patients.
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Aliment. Pharmacol. Ther. · Sep 2008
Meta AnalysisMeta-analysis: zinc supplementation for acute gastroenteritis in children.
Uncertainty exists regarding the use of zinc in the treatment of acute gastroenteritis in children living in Europe, where zinc deficiency is rare. ⋯ These data confirm that zinc supplementation can be useful for treating acute gastroenteritis in children, particularly those from developing countries. However, the role of zinc supplements in treating children with acute gastroenteritis in developed countries needs further evaluation.
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Aliment. Pharmacol. Ther. · Sep 2008
Randomized Controlled Trial Comparative Study Clinical TrialClinical trial: oral feeding with a soft diet compared with clear liquid diet as initial meal in mild acute pancreatitis.
In mild acute pancreatitis, traditional treatment has been initial fasting and oral refeeding with clear liquids to prevent adverse gastrointestinal events such as pain. The diet is gradually progressed to soft solids and hospital discharge is planned based on patients' tolerance to a solid diet. ⋯ Oral refeeding with a soft diet in patients with mild acute pancreatitis can be considered safe and can result in shorter length of hospitalization.