Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Feb 2006
Efficacy and safety of rifabutin-containing 'rescue therapy' for resistant Helicobacter pylori infection.
Current 'rescue' therapies provide inadequate Helicobacter pylori eradication rates because of antibiotic resistance. ⋯ A 12-day course of low dose of rifabutin with an increased dose of amoxicillin and pantoprazole is well-tolerated and highly effective against dual-resistant H. pylori infection after failure of triple therapy.
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Aliment. Pharmacol. Ther. · Feb 2006
Randomized Controlled TrialLansoprazole, levofloxacin and amoxicillin triple therapy vs. quadruple therapy as second-line treatment of resistant Helicobacter pylori infection.
To test the efficacy of levofloxacin-based second-line therapy for resistant Helicobacter pylori infection. ⋯ Lansoprazole, amoxicillin plus levofloxacin second-line therapy is comparable with quadruple therapy in efficacy. Subjects, especially those with dual resistance to metronidazole and clarithromycin, may consider levofloxacin-based therapy for levofloxacin-sensitive strains.
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Aliment. Pharmacol. Ther. · Jan 2006
Meta AnalysisMeta-analysis: Smectite in the treatment of acute infectious diarrhoea in children.
Although not currently recommended, dioctahedral smectite (smectite) is commonly used to treat acute infectious diarrhoea in many countries. ⋯ Smectite may be a useful adjunct to rehydration therapy in treating acute paediatric gastroenteritis. However, the results of this meta-analysis should be interpreted with caution as most of the included studies had important limitations. Cost-effectiveness analyses should be undertaken before routine pharmacological therapy with smectite is recommended.
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Aliment. Pharmacol. Ther. · Jan 2006
Randomized Controlled TrialTreatment of acute infectious diarrhoea in infants and children with a mixture of three Lactobacillus rhamnosus strains--a randomized, double-blind, placebo-controlled trial.
Multiple studies document that probiotics are effective in treating infectious diarrhoea in children. Lactobacillus rhamnosus GG is the most extensively studied but effectiveness of other strains has been poorly examined. ⋯ Administration of L. rhamnosus strains shortens the duration of rotaviral diarrhoea in children but not of diarrhoea of any aetiology. Intervention shortens the time of intravenous rehydration.
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Aliment. Pharmacol. Ther. · Jan 2006
Upper gastrointestinal bleeding associated with antiplatelet drugs.
The risk of major upper gastrointestinal bleeding associated with various antiplatelet drugs and the protection conferred by gastroprotective agents are not well defined. ⋯ The risk of upper gastrointestinal bleeding is substantially decreased by the concomitant use of proton pump inhibitors. The risk of acetylsalicylic acid plus a proton pump inhibitor seems lower than that of ticlopidine or clopidogrel.