Pediatric nephrology : journal of the International Pediatric Nephrology Association
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Comparative Study
Comparing cystatin C and creatinine in the diagnosis of pediatric acute renal allograft dysfunction.
Allograft function following renal transplantation is commonly monitored using serum creatinine. Multiple cross-sectional studies have shown that serum cystatin C is superior to creatinine for detection of mild to moderate chronic kidney dysfunction. Recent data in adults indicate that cystatin C might also be a more sensitive marker of acute renal dysfunction. This study aims to compare cystatin C and creatinine for detection of acute allograft dysfunction in children using pediatric RIFLE (risk of renal dysfunction, injury to the kidney, failure or loss of kidney function, end stage renal disease) criteria for acute kidney injury. ⋯ In this pediatric population, cystatin C was not superior to creatinine for the detection of acute allograft dysfunction.
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Urine interleukin-18 and cystatin-C as biomarkers of acute kidney injury in critically ill neonates.
Urinary interleukin-18 and cystatin-C are suggested to be biomarkers for predicting acute kidney injury (AKI). The aims of this study are to examine whether the urinary concentrations of interleukin-18 and cystatin-C vary with gestational age and other factors in non-AKI control neonates, and to determine whether urinary interleukin-18 and cystatin-C can predict AKI development in non-septic critically ill neonates, independently of potential confounders. ⋯ The urinary concentration of cystatin-C, but not interleukin-18, may decrease with increasing renal maturity. Both urinary interleukin-18 and cystatin-C are independently predictive of AKI in non-septic critically ill neonates.
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Editorial Historical Article
A history of the International Pediatric Nephrology Association (IPNA).