Molecular and cellular probes

The most recent articles from: Mol. Cell. Probes February 2018

Mol. Cell. Probes · Feb 2018

Generation of conditional Acvrl1 knockout mice by CRISPR/Cas9-mediated gene targeting.

This study aimed to generate mutant mice containing the Acvrl1 gene flanked with LoxP sequences to allow conditional deletion of Acvrl1 by the LoxP/Cre system. Such mice may facilitate the development of brain arteriovenous malformation (BAVM) models. ⋯ CRISPR/Cas9 is a reliable gene-editing tool, and is able to efficiently modify Acvrl1 and create the target mice.

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