Paediatric and perinatal epidemiology
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Paediatr Perinat Epidemiol · Nov 2013
Randomized Controlled Trial Multicenter StudyA randomised trial to evaluate the effects of low-dose aspirin in gestation and reproduction: design and baseline characteristics.
Low-dose aspirin (LDA) has been proposed to improve pregnancy outcomes in couples experiencing recurrent pregnancy loss. However, results from studies of LDA on pregnancy outcomes have been inconsistent, perhaps because most studies evaluated LDA-initiated post-conception. The purpose of the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial was to determine whether preconception-initiated LDA improves livebirth rates in women with one to two prior losses. ⋯ We describe the study design, recruitment, data collection, and baseline characteristics of participants enrolled in EAGeR, which aimed to determine the effect of LDA on livebirth and other pregnancy outcomes in these women.
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Paediatr Perinat Epidemiol · Nov 2013
Analysis of self-selection bias in a population-based cohort study of autism spectrum disorders.
This study examined potential self-selection bias in a large pregnancy cohort by comparing exposure-outcome associations from the cohort to similar associations obtained from nationwide registry data. The outcome under study was specialist-confirmed diagnosis of autism spectrum disorders (ASDs). ⋯ Associations estimated between ASDs and perinatal and prenatal exposures in the cohort are close to those estimated in the nationwide population. Self-selection does not appear to compromise validity of exposure-outcome associations in the ABC study.
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Paediatr Perinat Epidemiol · Nov 2013
Maternal pre-pregnancy body mass index and risk of selected birth defects: evidence of a dose-response relationship.
This study investigates the relationship between maternal pre-pregnancy body mass index (BMI) and 26 birth defects identified through the Florida Birth Defects Registry. ⋯ This study provides evidence of the increasing risk of birth defect-affected pregnancy with increasing pre-pregnancy obesity. Reducing pre-pregnancy obesity, even among obese women, may reduce the occurrence of birth defects.