Brain injury : [BI]
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Brain injury : [BI] · Jan 2013
Randomized Controlled TrialEffect of COMT Val158Met genotype on attention and response to methylphenidate following traumatic brain injury.
To investigate whether COMT Val158Met allele status was associated with (i) attentional performance and (ii) response to methylphenidate (MP) following traumatic brain injury (TBI). ⋯ COMT allele status was not strongly associated with attentional performance or response to MP in the TBI sample. The met/met group, whilst performing slowly, had relatively preserved strategic control of attention.
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Brain injury : [BI] · Jan 2013
Clinical TrialEvaluating the impact of treatment for sleep/wake disorders on recovery of cognition and communication in adults with chronic TBI.
To longitudinally examine objective and self-reported outcomes for recovery of cognition, communication, mood and participation in adults with traumatic brain injury (TBI) and co-morbid post-traumatic sleep/wake disorders. ⋯ These results add to a small but growing body of evidence that sleep/wake disorders associated with TBI exacerbate trauma-related cognitive, communication and mood impairments. Treatment for sleep/wake disorders may optimize recovery and outcomes.
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Brain injury : [BI] · Jan 2013
Comparative Study Controlled Clinical TrialEffects of dexmedetomidine on cerebral blood flow in critically ill patients with or without traumatic brain injury: a prospective controlled trial.
To examine the effect of dexmedetomidine on CBF in critical ill patients with or without TBI. ⋯ Dexmedetomidine may be used in patients with TBI without risk of affecting brain oxygenation.
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Brain injury : [BI] · Jan 2013
ReviewPlacement of intracranial pressure monitors by neurointensivists: case series and a systematic review.
Placement of an intracranial pressure (ICP) monitor to guide the management of patients with severe traumatic brain injury (TBI) has been historically performed by neurosurgeons. It is hypothesized that ICP monitors can be placed by non-surgeon neurointensivists, with placement success and complication rates comparable to neurosurgeons. ⋯ It is believed that insertion of ICP monitors by neurointensivists is safe and may aid in providing prompt monitoring of patients with severe TBI.
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Brain injury : [BI] · Jan 2013
ReviewEmerging pharmacological agents to improve survival from traumatic brain injury.
To review emerging pharmacological agents for the treatment of traumatic brain injury with regard to survival outcomes and provide recommendations regarding their use. ⋯ Emerging pharmacological agents represent promising treatment options for traumatic brain injury to improve survival. Most of these agents are commercially available for other indications. However, limitations in study design, sample size, duration of treatment, timing of treatment and inclusion of heterogeneous patient populations make it difficult to draw definitive conclusions from the literature.