Brain injury : [BI]
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Brain injury : [BI] · Jun 2013
Predictive value of initial intracranial pressure for refractory intracranial hypertension in persons with traumatic brain injury: a prospective observational study.
Abstract Objective: To prospectively investigate the predictive value of initial intracranial pressure (ICP) for refractory intracranial hypertension and outcomes in persons with diffuse traumatic brain injury (TBI). ⋯ For persons with diffuse TBI, the initial ICP provides great prognostic discrimination and is an independent predictor of refractory intracranial hypertension.
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Worse functional outcomes after controlled cortical impact (CCI) in Bace1(-/-) mice have previously been demonstrated. This study investigated whether reconstitution of amyloid-beta (Aβ) after CCI in Bace1(-/-) animals would reverse the detrimental effect of Bace1 deletion. ⋯ The data suggest Aβ40 may have some beneficial effects after CCI in young adult mice and that therapies targeting BACE should be approached cautiously.
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Brain injury : [BI] · Jan 2013
Review Case ReportsCase series evidence for improvement of executive functions after late cranioplasty.
Craniectomy, used to relieve refractory intracranial pressure in traumatic brain injury (TBI), may cause cognitive deficits which could be improved by skull breach repair. This paper studied whether late cranioplasty improves a specific pattern of cognitive functions. ⋯ The cognitive improvement induced by cranioplasty, even when performed after a long interval from craniectomy, may be due to the restoration of physiological cerebrospinal fluid circulation which, in turn, allows an efficient brain volume transmission signal circulation. The restoration of this essential way of signal communication seems to affect large-scale neuronal networks responsible for the executive functions.
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Brain injury : [BI] · Jan 2013
Review Meta AnalysisMeta-analysis of Glasgow coma scale and simplified motor score in predicting traumatic brain injury outcomes.
To perform a systematic review and meta-analysis to compare the simplified motor score (SMS) and Glasgow Coma Scale (GCS) in predicting outcomes in patients with traumatic brain injury (TBI). ⋯ In patients with TBI, SMS predicts different outcomes with similar accuracy as GCS except mortality. However, due to heterogeneity and limited numbers of studies, further prospective studies are required.
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Brain injury : [BI] · Jan 2013
ReviewPlacement of intracranial pressure monitors by neurointensivists: case series and a systematic review.
Placement of an intracranial pressure (ICP) monitor to guide the management of patients with severe traumatic brain injury (TBI) has been historically performed by neurosurgeons. It is hypothesized that ICP monitors can be placed by non-surgeon neurointensivists, with placement success and complication rates comparable to neurosurgeons. ⋯ It is believed that insertion of ICP monitors by neurointensivists is safe and may aid in providing prompt monitoring of patients with severe TBI.