Brain injury : [BI]
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Brain injury : [BI] · Jan 2011
Hyperphosphorylated neurofilament NF-H as a predictor of mortality after brain injury in children.
The aim of the study was to determine whether serum levels of hyperphosphorylated neurofilament NF-H correlate with severity of brain injury in children. ⋯ Although further, prospective study is warranted, these findings suggest that levels of hyperphosphorylated neurofilament NF-H correlate with mortality and may be useful as predictors of outcome in children with TBI.
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Brain injury : [BI] · Jan 2011
Exploring the sources of 'missingness' in brain tissue monitoring datasets: an observational cohort study.
To investigate the frequency/category of missing electronic data in export files from patients admitted to the intensive care unit (ICU) with severe traumatic brain injury (TBI). ⋯ Sixty-two patients were studied; 60% of missing T(br) and ICP data events were attributed to electronic data acquisition 'faults'. Missing data rate ranged from 9-43% (median 25%). Cross-reference of missing data to clinical observation sheets and medical case notes shows that disconnection of sensors from monitors during critical events are common. Conclusions and implications for further research: Of concern for clinical management of patients with TBI is the detection of sudden changes in ICP or brain temperature; the parameters which forewarn of impending intracranial catastrophes. Missing data occurred at critical times of the patients stay in the ICU. This work should alert research clinicians of the need to scrutinize monitored physiological data to establish the percentage of missing values in order to obviate bias in the interpretation of results.
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Brain injury : [BI] · Feb 2010
Relationships among post-concussive symptoms and symptoms of PTSD in children following mild traumatic brain injury.
To investigate the occurrence of post-concussive symptoms (PCS) and symptoms of post-traumatic stress disorder (PTSD) in children following mild traumatic brain injuries (TBI). ⋯ Although PCS and symptoms of PTSD are correlated, children with mild TBI are more distinguishable from children with OI based on PCS than on symptoms of PTSD. The latter symptoms, moreover, do not account for increased PCS following mild TBI in children.
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Brain injury : [BI] · Feb 2010
The pattern of traumatic brain injuries: a country undergoing rapid development.
Traumatic brain injuries (TBIs) remain an important public health problem in most industrial developed and especially in developing countries. This may also result in temporary or permanent disability. ⋯ The present study findings revealed that traumatic brain injury is a major public health problem, especially among young adults and older people. Although there was a sharp increase found in the number of TBI cases, the incidence rate of TBI took a stable trend during the study period.
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Brain injury : [BI] · Jan 2010
Review Meta AnalysisMagnesium sulphate in the management of patients with aneurysmal subarachnoid haemorrhage: a meta-analysis of prospective controlled trials.
Experimental and clinical studies have suggested that magnesium has neuroprotective and vasodilatation properties. A meta-analysis was conducted to assess the effectiveness and safety of intravenous magnesium therapy in patients with aneurysmal subarachnoid haemorrhage (SAH). ⋯ The meta-analysis suggests that intravenous magnesium therapy reduces the risk of DCI and poor outcome after aneurysmal SAH. Serum magnesium should be routinely monitored for both effectiveness and safety considerations.