Fundamental & clinical pharmacology
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The aim of this study was to document the influence of hyperthermia on the pharmacokinetics of ertapenem. Two groups of Wistar rats, normothermic (n = 6) and hyperthermic (n = 8), were injected a single intravenous bolus of ertapenem (15 mg/kg of body weight). ⋯ Hyperthermia induced significant higher plasma concentrations and exposure, whereas total apparent clearance and volume of distribution were significantly decreased. If confirmed in humans, these results will be of interest to take into account such modifications in hyperthermic clinical situations.
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Fundam Clin Pharmacol · Jun 2008
Abstracts of the 12th Annual Meeting of the French Society of Pharmacology and Therapeutics, the 75th Annual Meeting of the Society of Physiology, the 29th Pharmacovigilance Meeting, the 9th APNET Seminar and the 6th CHU CIC Meeting. April 9-11, 2008, Clermont-Ferrand, France.